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Trial registries currently contain limited methodologic information about registered RCTs.
Previous studies have shown that methodologic information is often inadequately described in RCT protocols [20] [25].
Trial registries have the potential to contribute important methodologic information for critical appraisal of study results.
Full protocols remain the most comprehensive source of methodologic information and should be made publicly available.
Full trial protocols remain a key source of methodologic information, and should be made publicly available.
To complement the limited methodologic information available on trial registries, the Ottawa Statement (http://ottawagroup.ohri.ca).
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Sensitivity analysis was performed to examine the effect of studies lacking information on methodologic quality on the pooled estimates.
The present study provides a methodologic approach and sequence information to carry out a large-scale screening of mating-type loci organization in Z. sapae and Z. rouxii.
They also reported a nonstatistically significant trend for the association of 24-hr urinary cadmium with the prevalence of PAD; however, in the absence of information on relevant methodologic details, such as the number of subjects with PAD, this nonsignificant result is difficult to interpret.
In addition, if the individuals registering the trial have an administrative rather than a scientific background, they may not have sufficient methodologic knowledge to properly register the information.
Most of the current research comprises initial exploratory studies that suffered from methodologic flaws, including small sample size, nontransparent patient information, lack of replication, and poor statistical analysis.
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