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There are currently only limited standardized methodologic guidelines for the assessment of CNS complications after cardiac surgery, which has resulted in considerable interstudy variability in the identification and reporting of outcomes.
41– 43 Current methodologic guidelines emphasize the importance of preference-based measures in comparative effectiveness studies of health technologies.
We followed the general methodologic guidelines developed within the framework of the APHEA-2 project, described in detail elsewhere (Touloumi et al. 2004).
This group carried out the following tasks: determine the needs of current and future environmental health policies; define the scope and target of the indicators; produce the methodologic guidelines for each of the indicators; pilot test the indicators and then further refine the indicators; and select a core set of indicators for pilot implementation.
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Nevertheless, such methodologic art can be addressed methodologically through guidelines that identify the options or strategies available and suggest how appropriate choices can be made from such options or strategies.
Although many of the studies were published prior to the development of current methodologic standards (e.g., the CONSORT guidelines) and hence cannot be faulted for the weaknesses they manifest, the tabular presentation of those weaknesses at this point in time may be useful for guiding future studies in this area.
The substantial methodologic difficulties existing in this area were outlined and guidelines were laid out, fueled in part by recent collaborations such as Interlymph and the NCI Cohort Breast and Prostate Cancer Consortium, on how to design, conduct, and analyze data from large, collaborative efforts.
This appraisal aims to evaluate each individual NASS guideline using AGREE II tool to demonstrate its methodologic robust and weakness.
This is consistent with the AHA 2010 guidelines for resuscitation and cardiovascular emergency, but more studies with good methodologic quality and large numbers of patients are still needed to make further assessment.
We will, however, encourage guideline developers to describe the variation among studies and to point out methodologic flaws.
Methods We review the design and analysis requirements, along with recruitment and eligibility guidelines, for dose-ranging studies of oral antihypertensives in children in light of ethical and methodologic issues unique to pediatric research.
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