Furthermore, although the results of studies of mobile phone risks have received widespread public attention, their interpretation is not straightforward because of methodologic difficulties.
OBJECTIVE: The effects of childhood exposure to parental problem drinking remain unclear because of inconsistent findings and methodologic difficulties in previous studies.
Similarly, regarding indirect costs, we did not assess productivity losses associated with reduced efficiency at work (absenteeism) and with unpaid work (for example, household work) because methodologic difficulties are involved in measuring these losses, and the size of the difference between study groups was expected to be minimal.
This state of affairs is a testimony to the real methodologic difficulties that pervade this research area.
Various methodologic difficulties may have obscured a true greater impact.
Methodologic difficulties involved in investigating prenatal exposures in nonwhite and/or disadvantaged populations are not trivial; nonetheless, this type of investigation must be done to fully understand life course processes that can culminate in breast cancer among women of any background.
The GeneSTAR study is the most comprehensive assessment of platelet response to aspirin done to date and given the cost, labor intensiveness, and methodologic difficulty in measuring platelet function across multiple agonists and doses in a large sample size, it is unlikely that another study of this magnitude will exist to support external validation of association signals.
There were difficulties, of course.
The difficulty of this task is compounded by several realities: the intrinsic methodologic limitations of both animal and human observational studies, the impact of mixed and multiple exposures, and complex work environments, both traditional and transitional.
"The difficulty of correlating,….
