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On the imaging side, key methodologic advances of this work include implementation of a simple, versatile, and efficient approach to multiparametric mapping, using a single detector.
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Since these early studies, the application of both technologic and methodologic advances to the investigation of blood has led to an ever-increasing understanding of the nature and function of the different types of blood cells.
Methodologic advances in the reconstruction of past ozone exposure are seen as essential, as is the incorporation of emerging markers of biologic response to ozone into traditional epidemiologic study designs.
Chief among the recent developments in methodologic advances has been the refinement of concepts and methods for measuring individual lead dose.
The methodologic advances have included the selection of pre-existing outcome measures that detected change in a sensitive fashion (in rheumatoid arthritis, this was the Core Set Measures).
Chief among the recent developments in methodologic advances has been the refinement of concepts and methods for measuring individual lead dose in terms of appreciating distinctions between recent versus cumulative doses and the use of biological markers to measure these parameters in epidemiologic studies of chronic disease.
Though many research challenges exist today, recent technologic and methodologic advances have been made that allow researchers to overcome some of these obstacles.
Recent TCE PBPK modeling efforts, coupled with methodologic advances in characterizing uncertainty and variability, suggest that rigorous application of PBPK modeling to TCE risk assessment appears feasible at least for TCE and its major oxidative metabolites trichloroacetic acid and trichloroethanol.
These and other methodologic advances resulted in being an invited speaker at an NIH/NIA conference on Longitudinal Methods and another on Clinical Trial Design.
For instance, since 2001, there have been several additional TCE-specific PBPK modeling efforts as well as more general methodologic advances in characterizing PBPK model uncertainty and variability.
Over the past half-century, methodologic advances have provided an increasingly strong quantitative basis for estimating the human health risks associated with exposures to environmental contaminants.
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