Primarily, methodical data on sampling, study design, explored constructs, and definition of outcome criteria were extracted from all selected studies.
Primarily, methodical data on sampling, study design, intervention procedure, and outcome criteria were extracted from all selected studies.
These include methodical harmonization concerning sample collection, processing, and analysis with the traceability of measurement results as well as the realization of well-designed prospective studies based on power analysis and sample size calculations.
Therefore, when studying different biomarkers in one EBC sample, the methodical setting often is based on a compromise and should be appropriately evaluated [ 6].
The process is methodical and scrupulous – every sample is cross-checked by three people to ensure accuracy of results, and positive cases are responded to within 24 hours, patients receiving free medication and regular follow-up visits by health workers to ensure compliance with the treatment.
To minimise sample-to-sample variability, repeated multivariate measurements in the same object (organ or tissue, e.g. PT-AT in lung) across patients should be designed, but prediction and validation on the genome scale with small sample size is a great methodical challenge.
The main aim of this work is to describe and demonstrate a methodical calibration approach which is based on Latin hypercube sampling and Kriging.
This lack of relation could be due to methodical problems of PPAR γ detection in archived tumor samples and in the complexity of TZD action.
In such measurements some methodical problems arise, which bring about inconsistency of the data samples combined from different sources; this work describes the problems at hand and proposes solutions on how to eliminate the inconsistencies.
