This method is highly sensitive, but has some methodical limitations that must be addressed.
EBC is an attractive non-invasive method for assessing airway diseases but its clinical use is still hampered by methodical limitations [ 5].
A few methodical limitations should be mentioned.
We are aware of the methodical limitations in this study.
There are several methodical limitations in this study.
The utility scores elicited within this study are consistent across six countries, suggesting methodical limitations were minimal.
Citation analysis is used as an indicator for the impact of publications for the scientific community, and, in consideration of methodical limitations, for research quality.
Apart from the limitations relating to the duration of hypoxia and the assessment of dynamic autoregulation, there are a number of methodical limitations relating to the assessment of CBF by TCD that also merit clarification.
Because of the complex three-dimensional cellular interactions and heterogeneity of mucosal cells in vivo, there are methodical limitations to the use of monolayer in vitro models and cultures with tumor cell lines.
Due to methodical limitations (e.g. LOD) and the strict criteria of MetExtract software, it is to be expected that especially low abundant metabolites might be missed in some samples.
