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Without the beat, the game would be a merely methodical challenge, with enemies moving every time you do, and all the time in the world to plot out the best line of attack.
Various proposals also exist to factor-out direct human-induced impacts from indirect human-induced and natural impacts [5, 11, 15], scientific approaches could not solve it [14, 43] and it remains a methodical challenge [39].
To minimise sample-to-sample variability, repeated multivariate measurements in the same object (organ or tissue, e.g. PT-AT in lung) across patients should be designed, but prediction and validation on the genome scale with small sample size is a great methodical challenge.
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This is due to the methodical challenges, like the absence of the possibility to detect and observe the nanomaterial and its behaviour in a complex system.
It is far beyond the scope of this paper to discuss the methodical challenges that arise when only the item responses of the students are used as the dependent variable instead of the plausible values (and vise versa).
Evaluation of the appropriateness of information technical systems for complex professional usage in safety-critical contexts poses significant methodical and practical challenges.
Dan Balz, of the Washington Post, describes it as "a methodical march through the challenges she encountered as the nation's top diplomat".
In many ways, his methodical response to his lengthening challenge resembles that of the man he is trying to replace.
Nasa took a methodical approach, breaking the lunar challenge down into smaller goals that could be achieved on a single mission.
The game assumes those who like intellectual challenges also like methodical searching, which is not always the case.
In a first step, current production engineering projects are analyzed and present methodical, information-technical and organizational challenges regarding the project phase of concept planning are depicted.
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CEO of Professional Science Editing for Scientists @ prosciediting.com