The first GxG interaction in the table was the optimal two-locus GxG interactions identified by the original MDR method with significant testing accuracy but insignificant CVC).
There was a significant correlation (r = 0.89, P < 0.01) between the myocardial salvage index measured by the two methods, with an insignificant bias of −2.3 ± 7.4% of the LV (P = 0.20).
The level of thiol groups was determined according to the method of Ellman (1959), with insignificant modifications.
The following is the limitations of the study: 1) it may could not include all cases with birth defect due to the limitations of diagnostic methods, for example, defects with insignificant symptoms are not likely to be found in early years of childhood; 2) perinatal death prior to diagnosis was also not included in this study.
We applied our method to each simulated dataset, with insignificant supporting features removed by permutations, except for x = 0%, and we called significant peaks at 10% FDR level.
The SA had two steps: 1) a preliminary BACCO GEM-SA was conducted to identify a more accurate emulator sampling method and to screen out parameters with insignificant influence on model outcomes; and 2) final BACCO GEM-SA was conducted with optimal input design set for emulator training runs varying only the significant input parameters.
The possible benefit of the suggested method is initially to allow SNPs with insignificant p-values, but which have association with the phenotype, are selected for the first selection.
The most likely explanation, which is consistent with other studies, may be that both methods underestimate the number of carriers in families with insignificant family history [ 42], that is both methods underestimate the exceptional nature of the families, within the context of a lower population rate of breast cancer.
In the multivariate analysis, Cox regression was used to estimate predictors of shorter survival using the backward method for insignificant variables elimination with a removal criteria at less than 0.1.
The proposed HFHMM scheme obtained the best SIR scores on average among all tested algorithms, with insignificant advantage over Hu and Wang method.
