After using multiple imputation 18 to predict missing EQ-5D scores, we used the area under the curve method (with adjustment for baseline differences) 19 to estimate, for each participant, the quality adjusted life year (QALY) gain/loss that accrued over the trial period.
All categorical efficacy parameters were analyzed using a Cochran-Mantel-Haenszel method with adjustment for the stratification variables.
Other baseline characteristics (including admission rates and screening tests) were compared using the Mantel-Haenszel method with adjustment for age and sex.
With regard to actual data, for those participants who had complete study data, the baseline and post-intervention (6, 12 and 24 month) EQ-5D scores were used to estimate the QALY gain using the area under the curve (AUC) method, with adjustment for baseline scores [ 34].
Despite its clinical relevance, there have been no large multicenter studies to compare the effectiveness of RSI to non-RSI methods with adjustment for potential confounding factors and clustering in the ED setting.
The relationship between case/control status and each SNP showing some evidence of association by χ2 testing was also considered using additive and genotypic regression methods with adjustment for the covariates age and sex.
We compared subcortical infarctions (present or absent) in case subjects and control subjects using logistic regression methods with adjustment for age, sex, years of education, and apoE ε4 allele carrier status (model 1) and with additional adjustment for potential confounders or covariates (model 2).
We used Klingler's preservation method with minor adjustments [ 35, 36].
This study is the largest study from Kashmir Valley that has investigated risk factors of ESCC in this relatively high-risk region, using analytical methods and with adjustments for several potential confounding factors, and the largest study that has ever studied the association between hookah and nass use and ESCC.
The solute concentration is advanced in time by means of a 7 8th order Runge Kutta Fehlberg method with automatic adjustment of the time-step.
