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"For testing TB, we are still dependent on a 100-year-old test called Koch's method which looks for the presence of the disease-causing bacteria in spit," says Dr Sandeep Sen who runs a diagnostic centre in Patna, the Bihar capital.
More recently, however, a method which looks at normalizing the score distributions of PWMs was used so that observed changes were comparable between PWMs (Manke et al., 2010).
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The current screening standard for intestinal schistosomiasis is the Katz-Kato method, which look for eggs on slides of fecal matter.
Those methods, which look backward a few times a year to correlate sales with a few dozen variables, are dangerously outdated.
When such data are further collated into (bio monitoring data sets that expand large regions, similar rankings can also be obtained via diagnostic, eco-epidemiological methods which look into the occurrence or abundance of species in relation to multiple stress [4].
Thus, two conclusions can be drawn here: first the "different methods for different HTs" statement is mainly due to the origin of the HTs, and second even though it seems to be true for GC content, codon usage or dinucleotide based methods, it doesn't apply to tetranucleotide based methods which look rather insensible to all HT criteria.
In contrast to those methods which look for the best templates, alignments and models, our approach tries to combine complementary and alternative templates, alignments and models to achieve on average better accuracy.
Here we modify the original method of, which looks at discrepancy only in respect to P, and instead define discrepancy as the minimum of the individual discrepancy scores found from P and P′, to remove any bias towards row or column nodes.
Instead, scientists will try to determine whether the whale had been swimming through oil by using a method known as hindcasting, which looks at how bloated an animal's body is to calculate how long it has been dead, then retraces patterns in water currents to tell where the body might have drifted from.
Like Kepler, TESS will use a detection method called transit photometry, which looks for periodic, repetitive dips in the visible light of stars caused by planets passing, or transiting, in front of them.
One method, using a "pricking iron", which looks like a fork, is laborious and hard to get straight; the other uses a "pricking wheel" – like a pastry edger – which zips along neatly but is much less satisfying.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com