The overall shape of the spectral function from the XY method is unchanged compared to the exact case.
Using a cut-off of 1.083 the specificity, in comparison with clinical performance measured using the CI method, is unchanged at 83.5%.
When using a cut-off of 0.390 the specificity, in comparison with clinical performance measured using the DP method, is unchanged at 38.5%, but sensitivity is significantly increased from 88.5%95%5% CI 79.7 94.4) to 96.6%, and NPV from 80.8 (95% CI 67.5 90.4) to 93.3% (Table 3).
We stress that in each of our experiments, the function prediction method is unchanged, and does not explicitly incorporate confidence or pathway information in any way, except in that it uses the values from the cDSD, caDSD or capDSD matrix instead of from the DSD (or ordinary shortest-path distance) matrix.
Comparable sets of experiments were carried out using the top-5% of the rankings to evaluate the various searches; the relative performance of the various methods was unchanged and we have hence included the results only for the top-1%.
The Ca2+ uptake speed, estimated by linear regression from the slope of the ascending phase of [Ca2+]m rise (see Materials and Methods), was unchanged in Afg3l2 −/− cells compared with syngenic controls (Fig. 2A).
The rankings of the methods are unchanged using cross-validated RMS error as the evaluation criterion (See Supplementary Section 10).
The mean preoperative apical rotation angle of 15.2 ± 5.5° was completely corrected after the C + D method (0°) and was unchanged after the C method (17.6 ± 4.2°).
The holding company's operating income before depreciation, amortization and noncash compensation expenses, its preferred method of measuring earnings, was unchanged at $480 million.
Though the methodology of the paper was imperfect, its result was unchanged after the method had been corrected, and geneticists have developed a growing confidence in mitochondrial DNA dates.
