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The machining mechanism of this method was thoroughly analyzed.
From this point of view, the adaptive notch filter method was thoroughly investigated.
This analytical method was thoroughly evaluated by applying risk assessment and multivariate analysis tools.
The developed method was thoroughly validated for its linearity, selectivity, precision and accuracy.
The optimized method was thoroughly validated, demonstrating to be selective, when the chromatogram was recorded with a diode-array detector and peak purities were evaluated (>0.9995).
The method was thoroughly validated using human plasma spiked with pharmacologically relevant concentrations of paclitaxel (10 1000 ng/ml) and Cremophor EL (0.25 2.0%).
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The method is thoroughly integrated into the isogeometric framework.
The fabrication method is thoroughly described in a previously presented work [8].
This improvement of control of the product quality provided by this PAT method is thoroughly compliant with the Quality by Design (QbD) concept.
Accuracy and stability of the method are thoroughly tested for the model problem of transitional and turbulent flows in an infinite circular pipe.
The proposed method is thoroughly validated via three numerical test cases of increasing complexity: a Rayleigh–Taylor instability, turbulent channel flow with a heated and a cooled wall, and turbulent flow past a backward-facing step with heating.
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