Can your R&D production method be scaled up? Cell flasks vs. cell factories Availability of GMP grade raw materials Automated aseptic processing e.g. sepax, COBE, cliniMACS, WAVE, prodigy What is the national/international manufacturing strategy i.e. hubs vs. single manufacturing centre?
Moreover, this method may be scaled up for large-scale production of ultralong hydroxyapatite nanowires.
This method can be scaled up for almost all kinds of substrates.
While at present it allows monitoring a Vβ/Jβ-specific fraction of 0.03% of the T-cell receptor repertoire on a single 4000-spot slide, the microarray-based method can be scaled up to monitor and screen a large pool of the T-cell repertoire for dominant clonotypes.
Additionally, the synthetic method can be scaled up to provide significant amounts of probe.
This method can be scaled up without any loss of reaction efficiency.
The method can be scaled up for large volumes and applied in clinical practice [ 137].
However, this expert-picking-based method cannot be scaled up for discovering drug combinations from a large set of drugs.
However, with increasing recommendations for the method to be scaled up at the national level, careful consideration needs to be given to addressing this issue as a significant challenge.
Because esMDMs maintain a stable and functional phenotype with time and the method can be scaled up to produce large number of cells, it will be particularly useful for investigating macrophage-specific functions in various diseases including atherosclerosis, sepsis, cancer, tuberculosis, and HIV-1.
Some suggest adopting Israel's security model, based on extensive interviewing of passengers, but Mr Schneier says its methods cannot be scaled up to accommodate America's tens of millions of passengers.
