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For reliability, another investigator, who was also familiar with the method used, repeated the clinical examination for 10% of the participants.
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Each recommendation was graded by each expert according to the RAND/UCLA appropriateness rating method, using repeated rounds of grading after exclusion of the extreme values (highly deviant expert ratings).
An alternative frequentist method uses repeated hypothesis tests to reject models one by one.
Therefore, taking into consideration the conventional intake methods, we used repeated maceration in 80%% ethanol to extract the active ingredients as much as possible.
Methods This study used repeated antenatal measurements of blood pressure from 12 996 women in the Avon Longitudinal Study of Parents and Children ALSPACC) to develop prediction models and validated these in 3005 women from the Southampton Women's Survey (SWS).
However, modifying the method by using repeated injections of hCG in smaller doses may give better results.
The sampling method was validated using repeated rounds of sample collection to demonstrate that ≥ 95% of the organic and bioburden residuals were recovered in the first round of sample collection and that there was no added value in more extensive sampling.
Using this limits of agreement framework, multivariate hierarchical Bayesian models provide an attractive alterative to the existing suite of analytic methods in measuring agreement using repeated measurement method comparison studies.
To verify whether our findings were related to the urinary protein method used, we repeated our statistical analyses in two separate published cohorts of women in which proteinuria was determined using a pyrogallol-based dye-binding urine protein assay [ 6, 7].
We dichotomised the EQ-5D levels into no problems (ie, level 1 as Y=0) and problems (ie, levels 2 and 3 as Y=1) due to the small number of responses citing level 3. Based on the distribution of the dependent variables, logistic regression was used for binary outcome variables and normal regression was used for VAS with the generalised estimation equation (GEE) method used for repeated measures.
Both models adjusted for clustering within individual database users using repeated effects method.
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