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We used z-score normalization method to normalize our time series data.
Normalization was performed using print-tip specific LOWESS to normalize within arrays and the quantile normalization method to normalize between arrays [53].
The cell intensity files (.cel) of all arrays were also analyzed using dChip software [ 15], which employs the invariant set normalization method to normalize the arrays.
Here we provide a solution to the challenging question of extracting CNAs from amplicon sequencing data by (i) defining a method to normalize read coverage with a small set of normal control samples and (ii) assigning statistical significance to putative CNAs resulting from the segmentation of normalized profiles.
Therefore, we propose a method to normalize them before performing NER.
This study also presents a method to normalize rate constants for changes in the power-to-volume ratio.
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Some other methods to normalize widely varying ranges of activity values are also reported in the literature.
CGHcall employs DNAcopy methods to normalize and smoothen the data and defines equal copy number segments for further analysis.
In addition, further studies are needed to assess the value of the different methods to normalize these CSH to baseline values (SUV and/or volume).
Apart from methods to normalize data and adjust them for technical bias, several algorithms to identify differentially methylated regions (DMRs) between groups of interest have been developed.
These methods are summarized briefly as follows: The ChemBank method aims to normalize the activity in the assay based on mock signals.
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