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Cryoelectron microscopy (cryo-EM) is an increasingly popular method to elucidate the structures of macromolecular complexes.
Hence, we approached using a mathematical and experimental method to elucidate the new scaffold׳s efficiency.
Fragment-based drug discovery is a powerful method to elucidate novel binding sites within proteins, and the method has had significant success in the context of HIV proteins.
The intermolecular and lattice energies of the compounds were studied using PIXELC method to elucidate the quantitative information on interactions appeared between the molecules.
Mass spectrometric structural analysis of crosslinked peptides is a powerful method to elucidate the spatial arrangement of polypeptides in protein complexes.
The present model provides an effective method to elucidate the damage behavior of brittle ceramic coating systems, and hence, it is expected to greatly aid the coating design.
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In conclusion, as proof-of-concept, we show that an SDL screen offers an effective, complementary method to elucidating biological functions of proteolytic pathways.
In conclusion, as proof-of-concept, we show that a synthetic dosage lethality screen, which is based on the toxicity induced by gene overexpression, offers an effective, complementary method to elucidating biological functions of proteolytic pathways.
Here, we used the photophysical and photochemical properties of this complex, as well as spectroscopic and computational methods, to elucidate molecular binding sites on Aβ fibrils.
This study highlights the need for robust structural and functional methods to elucidate the mechanisms of mutation in the development of next-generation synthetic genetic base pairs.
The three workflows illustrated in this paper demonstrate how one can use the toolkit to quickly prepare, filter, and screen data and apply various statistical methods to elucidate relationships.
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