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By applying the method to compounds with different Henry's law constants, the application range of the method was demonstrated regarding solubility in water.
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We used the method to identify compounds that target protein-protein interactions.
A second part in the development of a generic flow injection analysis (FIA) method to determine compounds with a secondary amine or amide in their structure is described.
A generic flow injection analysis (FIA) method to determine compounds with a secondary amine or an amide in their structure was developed.
A screening method to seek compounds capable of keeping Aβ at the monomeric status is highly desirable.
We implemented a method to annotate compounds in a computational framework that allows the introduction of prior knowledge and additional spectral information.
We therefore hypothesised that matrix contraction by CAFs could be used as a screening method to identify compounds that prevent matrix remodelling and hence would reduce fibroblast-stimulated carcinoma cell invasion.
In contrast, LC-MS/MS provides a general method to measure compound concentrations relative to an internal standard.
Moreover, a novel method to identify new compounds that disrupt the function of ribosomes in Mycobacterium tuberculosis has identified two compounds (T766 and T054) with potent specific activity against M. tuberculosis and low toxicity to mice and other bacterial strains.
The development of specific databases based on expression profiles of reference compounds and the use of ever improving statistical methods to discriminate compounds on the basis of their gene expression profiles will result in highly informative gene clusters which can be used to predict the class membership of new unknown compounds (Hamadeh et al. 2002a).
Hydrogenation is the most widely used method to reduce organic compounds.
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