The above findings suggest that the probes we designed could act as ideal and easy method for investigating the pivotal role of H+ in lysosomes and are potential pH detectors in disease diagnosis through direct intracellular imaging.
The method is pivotal in that it neither relies on the knowledge of the standard deviation σ nor does it need to pre-estimate σ.
Approximate confidence intervals for the treatment mean difference and the individual means are constructed using the pivotal method of Woodroofe, and an approximation to the bias of the maximum likelihood estimator of the treatment mean difference is studied based on the work of Whitehead.
Such a method is pivotal to the confirmation of the integration of composites in the device and to enable determination of parameters, such as spatial alignment of incorporated 2D materials, dynamically during device operation.
Today as 50 years ago, the clinico-anatomical correlation method remains pivotal in our understanding of the complex relations between brain and behavior (Mah et al. 2014).
The case of Anna O. introduced Freud to the cathartic method (the "talking cure") that was pivotal in his later work.
The decoding method plays a pivotal role for improving the solution quality of any algorithm for the HFS problem.
However, in view of the pivotal roles played by MHC genes, scientists have developed elaborate methods for exploring these genes.
An efficient method for generating 3D curvilinear wire-frames from three orthographic views is presented, which is the pivotal stage of solid reconstruction by wire-frame-oriented approaches.
Since the accuracy and precision of the final result is composed of the accuracy and precision of the cell count and the final analysis, an accurate and precise cell counting method is pivotal to obtain correct results.
