Although we describe the specific process for refining BCD's aberration-detection method, the issues presented are common across jurisdictions, and the principles and results are likely to be generalizable.
These include the cohort size in relation to subgrouping, the balance between strengths and weaknesses of our selection of registration methods, the issue of whether microstructural abnormalities are primary or secondary to MDD, and medication status of patients.
We notice here that, independently to the normalization method used, the issue of isoform switch can influence the expression results, leading to erroneous DE analysis.
This method overcomes the issue of limited cells by pooling multiple cell populations together after on-bead indexing of the sonicated, chromatinized DNA.
Therefore, for this kind of image fusion method the key issue is its fusion rule design, and it should be paid more attention.
Hence, it would be unwise to try only one classification method: the multiplicity issue investigated in this study is relevant.
With the in-channel method, the incompatibility issue of RhB and PDMS is greatly reduced and the experimental results showed excellent agreement with the numerical simulations.
An alternative method: The key issue here is whether the spindle complex that contains TACC3 and clathrin is able to bundle MTs in vitro.
The methods address the issue by allowing multiple aspects to be taken into consideration.
Both methods raise the issue of underreporting and measurement error.
