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GSEA is a computational method that ascertains whether a given gene set (in our case derived from the different normal and malignant tissues) is significantly enriched in a list of genes ranked by their correlation with a phenotype of interest (herein the various genetic subtypes of childhood leukemia).
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Compared to methods that ascertain individual-level exposure, some additional measurement error is likely from this group-based approach.
We analysed the time from seroconversion to AIDS via Cox proportional hazard model, a method that allows for late entry and inclusion of retrospectively ascertained seroconversion [ 11].
Last but not least, we adopt the Chebychev collocation method, that uses backward Euler method and the Gauss-Lobatto points, to provide numerical simulations in order to ascertain the correctness of the theoretical outcomes.
A major obstacle for industrial use of respective coatings is the lack of adapted characterisation methods that permit to ascertain corrosion protective function.
13 The authors noted that most of the studies did not describe the randomisation method and that ascertaining whether allocation was concealed was not possible for most of the 19 trials reviewed.
We used similar statistical methods that were used in prior thickness studies [58], [75], [76], [77] to ascertain surface-based group differences using the general linear model tools within FreeSurfer.
Suicide method was ascertained from that recorded in the ONS Certificate of Death [ 25] (ICD-10 codes) [ 26] and the following groups were considered: hanging - X83.8, drowning - X71, cutting - X78, poisoning - X64 and Y1, jumping (either from high place or in front of a vehicle) - X80, X81, burning - X76, X77 and undetermined cause of death - Yxx.
The method ascertains that, unlike in more classical approaches, after finding the global minimum and a number of local ones on the way, the algorithm continues the exploration and identifies new local minima.
We have shown that this method ascertains approximately 90% of incident cancers.[13] Our end points were first primary incident cancers, defined according to the Surveillance Epidemiology and End Result (SEER) criteria, with minor modifications for malignancies of the head and neck, esophagus, pancreas, and prostate, as described previously.[14] [18] Skin cancer was restricted to melanoma only.
To use the comparative CT method, we ascertained that the efficiencies of the target and endogenous control amplifications were approximately equal.
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