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While interesting, this method remains invasive [ 51] and requires frequent recalibration when the vasomotor tone changes [ 52- 55].
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Although muscle biopsy remains the diagnostic method of choice for detection of structural abnormalities, it remains invasive and therefore is not a practical screening tool.
Nevertheless, the test remains invasive, requiring an angiogramme.
However, this procedure remains invasive, expensive, and inconvenient for patients.
Yet enhancing EPC homing to the damaged areas of arteries through a minimally invasive method remains a challenge for vascular endothelialization.
Radical cystectomy is quite an invasive procedure and exhibits significant complications; this method remains unsatisfactory and little progress has been made to correct these issues in recent years.
For all that, the method remains simple.
However, the best method remains unknown.
Nevertheless, accuracy of these methods remains debatable.
The main advantage of this optical method compared to others in molecular imaging is that it remains non invasive and non-ionizing.
Although less invasive than pulmonary artery catherization, femoral or radial arterial catheterization remains an invasive procedure.
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