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Subsequently, we apply our method on phenotype dataset.
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Based on an early disease-gene screening method based on phenotype similarity or network topological properties and the advances of genome sequencing, gene expression analysis and other parallel technologies, it is clear that new disease-gene screening methods are emerging [ 54, 65, 66].
On the other hand, the model by Jørgensen et al. (2009) is based on methods of phenotype optimization that give indications of where evolution may eventually lead.
We thank Merete Fredholm for testing our method on collected phenotype data on the pig population and the BioChild consortium http://www.biochild.ku.dk for the use of the high-throughput genotype data on those animals.
It was also shown that proline accumulation under stresses was not necessarily linked with drought or salinity tolerance based on methods of phenotyping used in this experiment.
We apply the selected methods on the phenotype "Mouse Running Distance at day 5/6".
The biological functional analysis based on the MAQC-II breast cancer dataset convinced us to apply our method for phenotype prediction.
Methods of phenotyping and selection for drought resistance are dealt with in detail concentrating again on proven utility, especially under field conditions.
Figure 1 shows that relative performance of each method substantially depends on phenotypes, and least AUCs are often observed for SI, followed by SC.
Furthermore, we investigated the effects of NF-κB decoy transfection by this method on the tumor-promoting phenotype of TAMs as well as MA progression.
Several rheumatic disease studies are already utilizing powerful methods to determine epigenetic influences on phenotype and are discussed in multiple reviews [ 32- 35].
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