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This effect on TST reactivity is dependent on strain and dose of BCG used [5], [6], the method of vaccine administration [6], the time since vaccination [7], [8], the number of BCG vaccinations administered [9], the age, weight and nutritional status of the individual at the time of vaccination [8], [10] and genetic factors [11].
School-based vaccination is becoming a more widely used method of vaccine delivery.
Dr. Higgins is a co-founder of Genocea, a biotechnology start-up company working on a novel method of vaccine development.
The traditional method of vaccine development entails the trial and error of modifying infectious disease cells, then injecting them into humans or animals to see if the immune system responds with a near-perfect defense.
While the plan hasn't gone through final approval, it seems to be by far the most efficient method of vaccine distribution proposed.
However, the traditional method of vaccine development with blind passage could not fit the style of the emergency prevention of IBDV.
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Traditional methods of vaccine development have not produced effective vaccines for several prevalent infectious diseases, including AIDS, malaria and tuberculosis.
Contemporary vaccine development relies less on empirical methods of vaccine construction, and now employs a powerful array of precise engineering strategies to construct immunogenic live vaccines.
Here, we use new reverse genetic systems, based on the 230-kb mouse cytomegalovirus genome to explore new methods of vaccine delivery and of virus attenuation.
New methods of vaccine delivery other than injection will be used (e.g. mucosal administration) and new vectors or adjuvants will be added to vaccines in order to stimulate specific responses.
This is not feasible under current methods of vaccine production, but shortening the time of the production of vaccines has been a priority [17].
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CEO of Professional Science Editing for Scientists @ prosciediting.com