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From these observations we suggest that sequential HBI treatment technique with local radiation boost is an efficient method of tumour control in patients with early small-cell lung cancer.
Survival differences between the two groups of surgeons could be accounted for by differences in tumour size (lead-time bias) and also by method of tumour detection (length-time bias).
Figure 3 presents incidence rates by age according to the use of HRT and the method of tumour detection among the 400 patients (aged 50 74 years) with available data on HRT.
For experimental design we extracted data for species, strain and sex of animals; glioma cell type, tumour implantation site, tumour implantation method, number or volume of implanted tumour cells and method of tumour volume measurement (where relevant).
In the phase II part of the study, nine of the eligible patients were not evaluable for efficacy because two full cycles of treatment were not completed (n = 8) and/or the method of tumour assessment following treatment differed from that used at baseline (n = 9).
Multivariate survival analyses were done with the Cox proportional hazards model, entering the following covariates: automated assessment of Ki-67 extent of staining or visually assessed Ki-67 proliferation index, method of tumour detection, tumour size in centimetres, number of metastatic lymph nodes, histological grade, and age at diagnosis.
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Table 3 shows the methods of tumour detection and management of breast cancer according to familial risk.
Therefore, we would like to recommend the MMTV-Luc2 imaging as supportive tool to manual methods of tumour monitoring.
As more is understood about the methods of tumour propagation, hypoxia has become a critical microenvironmental influence.
RT-PCR is one of the most common methods of tumour cell detection because of its high sensitivity and specificity, assuming adequate primer and probe design.
Alternative methods of tumour control that exploit the immune-stimulating potential of radiation therapy are currently being explored (Kwilas et al, 2012; Formenti and Demaria, 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com