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We conclude that the method of tolerance assessment affects the ability to detect tolerance and thus may affect the degree and pattern of heritability of this trait and this could have implications for gene mapping studies.
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The aim of this study is to propose a variational method of tolerancing analysis using a multiphysical approach.
Calibration helps to reduce systematic errors of the measurement method, of tolerances of the used components due to manufacturing, deviations in the assembly, misalignment etc.
This work proposes to expand the current tolerancing practices, and presents a new optimization method of tolerancing mechanical systems using interval computation for the prediction of system response.
Based on these results, our idea was to combine established methods of tolerance induction to a specific marker with subsequent transplantation of otherwise syngeneic cells labeled with the same marker in order to avoid immune-mediated rejection of the labeled cells.
The analysis of these two methods of tolerancing shows that the system has a good tolerance.
The method of positional tolerancing has several advantages.
"We know you can do it," said Dr. Jeffrey Bluestone, director of the diabetes center at the University of California at San Francisco and director of the Immune Tolerance Network, which conducts clinical trials on methods of inducing tolerance.
As physical experiments are expensive, methods of statistical tolerance analysis tools are widely used in engineering design.
Because at the time of clinical diagnosis a significant proportion of the B-cell mass has been destroyed (although there may be less than has been appreciated because of the dysfunctional islets), restoration of B-cell mass should be attempted along with methods of immune tolerance; this can be accomplished by B-cell regeneration or substitution.
This method supplements the existing methods for tolerance improvement of industrial strains, for example gTME.
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