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4 The indirect method of standardisation was used to determine the standardised mortality ratio (SMR) for this cohort.
The indirect method of standardisation was used for internal comparisons[ 15].
This method of standardisation, which has been used before, uses 20 mg of enalapril as reference dose [ 15].
The direct method of standardisation was used and the WHO world population was used as the standard population.
We used the direct method of standardisation as described by Beaghole et al 28 for standard Portuguese population.
We used the indirect method of standardisation, taking the combined NF and reference cohorts as the standard population.
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This is the same problem for all methods of standardisation.
We have described methods of standardisation in an epidemiological setting to ensure accuracy and consistency.
Figures 2 and 3 compare the different methods of standardisation of hospital mortality rates in the HES data.
Misspecification of the model is likely to lead to invalid comparisons between centres for all methods of standardisation, including our proposed DRS method.
However, for the purposes of this study, which compares different methods of standardisation rather than different models for standardisation, we have simply used the same models for each of the methods in order to ensure comparability.
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