The methods of serum collection, analytical methods, and quality control standards have been published previously (Fingerhut et al. 1989, 1991; Patterson et al. 1986 , 1989 Turner et al. 1989).
It is 168 times faster than the existing, inaccurate method of measuring serum tumour markers, more sensitive and, at 5 cents (3p) each, cheap.
Given that mass spectra are prone to variability in ionization efficiency, we applied a standardized method of analyzing serum directly with MALDI-TOF MS, using averaging of technical replicates and normalization to a measure of total ionization efficiency by the laser.
Another examined acute renal injury in burn patients, and one described a novel method of assessing serum markers of burn severity.
We have applied a proteomic strategy using an optimised method of patient serum preparation in order to identify candidate biomarkers of either cirrhosis or HCC.
These results demonstrate that maintaining a low GI or glycemic load diet is an effective method of controlling serum glucose and insulin levels.
In this study, we firstly developed the method of blood serum detection by using SERS based on label-free Au nanoparticles to diagnose the parotid gland tumors preoperatively.
This method of quantitating serum samples against plasma calibration also met the FDA ± 15% method precision requirement for all target analytes and also met the FDA ± 15% method accuracy requirement for PFOS, M556, and M570.
Information, such as surname of first author, year of publication, source of publication, study type, study design, sample size, age, sex, ethnicity and country of origin, detection method of HMGB1 serum levels, and expression levels, was collected from each study.
