Fig. 6 Divergent quantitative diagnosis based on method of quantification.
In this research work, a method of quantification of the erosion is developed.
However, these two methods are quite different in regard to the method of quantification.
Because fluorescence is measured, the method of quantification is limited to fluorescent tracers and fluorescent colloidal suspensions.
Conversely with the Southampton method of quantification, partial volume factors are already accounted for, which can be seen by the much smaller differences in calibrated and non-calibrated values (Figs. 1 and 2).
This study on prodromal AD patients recruited according to strict inclusion criteria revealed, using an optimized method of quantification on the cortex only, increased cortical amyloid load compared to cognitively normal subjects.
In addition to nanoparticle approaches, lack of improper less selective and sensitive method of quantification makes it difficult to measure DOX concentration in any biological samples, following oral administration.
b A clinically abnormal study of a 65-year-old female patient with a 3-year follow-up diagnosis of a dopaminergic degenerative disorder (multiple system atrophy) which was normal using BRASS quantification with the exception of striatal and putaminal binding ratios using a calibrated FBP approach (and putamen non-calibrated) and rated abnormal with the Southampton method of quantification.
Using the BRASS method of quantification where tight VOIs are particularly susceptible to partial volume effects, the primary influence of the calibration is to correct for these effects, as can be seen in the pre- and post-calibration normal ranges with this method (Figs. 1 and 2, respectively).
On closer investigation, there is a tendency for the performance of putaminal SBRs with BRASS to perform slightly better than the assessment of full striatal SBRs with the same software, which in turn performs slightly better than the Southampton method of quantification.
The method of quantification is outlined in the Image J documentation: "Particle Analysis".
