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The main nonenhanced method of perfusion in MRI is arterial spin labeling (ASL).
Eight pigs were used to establish the method of perfusion measurement by MRI with an ultrasound flow probe as a reference method and adenosine administration to enhance perfusion.
In previous publications, authors of that method of perfusion evaluation have proved its usefulness in children, in adolescents, and in patients after kidney transplant [ 6, 17].
The method of perfusion imaging is effective to detect the differentiation of blood supply between benign and malignant pulmonary nodules in quantity and quality [ 4- 8].
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The most common methods of perfusion imaging are dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) MRI, the latter being used almost exclusively in brain imaging.
Furthermore the FAIR ASL method employed in our study has, in earlier studies [ 23], been validated against the gold standard of a microsphere perfusion method of renal perfusion measurement.
This method of quantifying perfusion has the advantage that it provides an estimate of the total perfusion of all the tumour volume selected and it is has been shown to have low interobserver variation.
Ultrasound particle manipulation is not harmful to cells and is a state-of-the-art method for perfusion filtering of mammalian cell cultures, where it is used to hold cells against a continuous flow of medium.
Another less invasive method of altering perfusion pressure is through experimental changes in systemic blood pressure.
The most common diagnostic method of assessing perfusion remains clinical evaluation, but there is increasing use of echocardiography.
Postoperative pediatric patients who have undergone cardiac surgery may benefit from venous saturation monitoring to assess oxygen delivery and as an indirect method of systemic perfusion.
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