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Mechanical action, until the 19th century the sole method of linkage between pipe and keyboard, is still commonplace.
The datasets generated in this study was treated by the Ward's method of linkage with squared Euclidean distance as a measure of similarity.
Hierarchical cluster analysis of 36 loci was performed, using correlation to measure the distance between any two loci and Ward's method of linkage [57].
On a broader scale it provides an insight in Lepidoptera sex chromosome evolution and it proposes a simpler and more reliable method of linkage mapping than used for Lepidoptera to date.
This could be an artefact caused by the method of linkage map construction [ 16], where flanking markers were used to correct putative data errors.
To reveal subgroups of peaks and patients, the dataset was analyzed by hierarchical clustering with the Ward method of linkage of clusters [ 24] and the distance measure was derived from the Spearman correlation matrix.
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Since the test for independence is not affected by segregation distortion like the LOD score used by other methods of linkage analysis, a lower incidence of spurious linkage is expected [ 74].
The strong concordance between different analytical methods of linkage and the replication of data between two independent studies suggest that these loci harbor ADHD susceptibility genes (Fig. 3) (Arcos-Burgos et al. 2004b).
In addition, it is essential to make allowance for mistakes in data entry particularly when using deterministic methods of linkage in which records are linked only if they match exactly [ 22].
The reasons for different rates of completeness in data linkage are varied but can be broadly grouped into the methods of linkage, governance issues, such as requiring consent for linkage, and the accuracy and completeness of the data within each data source.
The method of data linkage, imputation and statistical analysis used provides a basis for improved analysis of database linkage studies.
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