Regardless of whether clioquinol itself proves to be useful, "this should certainly spur efforts to find methods of intervening at the level of the iron," says Alzheimer's disease researcher Gregory Cole of the University of California, Los Angeles.
To exercise some control in the tribal areas, the Ottomans continued to rely on the traditional methods of intervening in the competition for tribal leadership, making alliances, pitting one tribal group against another, and occasionally using military force.
Thus, much interest exists, from both clinical and pharmaceutical points of view, in identifying methods of intervening within the TGFβ signaling cascade in such a fashion that the pro-fibrotic aspects of TGFβ signaling are blocked but other TGFβ-dependent processes are unaltered.
Second, the intervention would be undertaken with the consent of the individual so that the risk of paternalistic overreach would be minimized, and confined to "traditional" methods of intervening (as in the Stockholm Syndrome case, as well as the "cult leader" scenario).
Since cell surface gp96 induced significant DC activations [29],[32], we employed a chemical method to intervene over-maturation of DCs via gp96.
The study describes the impact of intervening in the early period of reperfusion applying a surgical method called postconditioning.
Sharma and Ganguly [ 4] call for urgency in reducing premature coronary artery disease risks and point to the prevention of CASHD before onset as a better suited method than intervening at a later stage of disease development.
Three methods for intervening in the amyloid cascade have thus far been tested in clinical trials: active immunization, passive immunization, and modulation of γ-secretase [ 4, 5].
However, developing culturally sensitive methods for intervening should be researched and developed.
