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This study was designed to further explore the possibility of using this method of HPV genotyping for routine application in a clinical laboratory to improve the specificity of the current HPV testing and its potential pitfalls.
They have been investigated as triage tool for equivocal Pap smear result (PCDH10) 34, or for high-risk HPV infection (CADM1 and MAL) 35, 36 with performances better than or noninferior to the traditional triage method of HPV test and Pap smear, respectively.
Herein, we report a novel detection method of HPV DNA combining the advantages of QDs and manipulability of superparamagnetic nanoparticles and validate it clinically.
Another method of HPV DNA detection in tumor samples is ISH.
Our sensitive method of HPV detection has been previously validated with other commonly used assays to detect HPV [ 39].
The method of HPV pseudovirion generated by intracellular assembly resembles a system more biologically similar to the natural environment for viral assembly.
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We evaluated two molecular methods of HPV detection and their correlation with cytological and histological diagnosis in a large sample of Greek women.
In evaluating the relation between oral contraceptive use and HPV infection, it may be appropriate to include, where possible, studies using different methods of HPV detection as these may reflect different aspects of HPV infection.
Where studies used more than one method of urine HPV testing, we included the method that was most similar to that of other studies in this review.
No other explanations of heterogeneity were identified by our metaregression, including analysis of the method for HPV detection and commercial versus non-commercial extraction and amplification methods.
28 35 37 39 44 We agree with previous reviews that heterogeneous methods of urine testing affect the interpretation of pooled accuracy measures and that a uniform method for detection of HPV in urine must be developed.
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