High levels of method discontinuation (45% of married women discontinue their method within the first 12 months of use) contribute to unmet need in Jordan.
In the osteoporosis field, these issues are of key importance given the growing interest in a 'drug holiday' [ 15, 16] during which time patients are instructed to cease bisphosphonate therapy for a time (e.g., 1 3 years), making additional work on methods for discontinuation of anti-osteoporosis drugs important and timely.
23 24 This poses a great challenge of discontinuation of methods by users and adoption of methods by non-users.
These include the ideal timing of the intervention, the proper use of adjuncts like volume recruitment maneuvers, prone position, or nitric oxide, the ideal timing of discontinuation, the proper methods to manipulate the various indices such as Paw, Δ P, and frequency, and the effects on long-term outcomes such as lung function.
Unintended pregnancy in Nepal is attributed to the reliance on short-term methods, which have a greater chance of method failure and discontinuation [ 2, 3].
The cumulative rate of discontinuation was calculated using the actuarial method with multiple-failure per patient.
The cumulative rate of discontinuation was calculated using the actuarial method, accounting for multiple failures per patient and for the calendar year.
Subdermal implants of etonogestrol are an effective method of contraception but have a high discontinuation rate often due to irregular uterine bleeding.
A second method of approaching the issue of severity of adverse events is to look at rates of discontinuation because of such events.
X-axis: causes of discontinuation.
