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Therefore, the consistent results obtained with the PEAarea method, validated by the direct measurements of LV d P/d tmax, strongly support the introduction of this new operator-independent method of CRT optimization into clinical practice and implantable devices.
Therefore, a direct comparison of a new method of CRT optimization, based on PEA measurements, with LV d P/d tmax, the haemodynamic gold standard, was of particular interest.
The attainment of concordant results with invasive haemodynamic measurements in the majority of responders warrant further testing of this operator-independent and expeditious method of CRT optimization in a larger patient population.
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Cumulative progression-free survival was calculated using the Kaplan-Meier method from the date of CRT initiation to the recurrence or death from any cause.
The overall survival was calculated using the Kaplan-Meier method from the date of CRT initiation to death from any cause.
Finally, the outcomes of CRT optimization based on the PEAarea method might not be predicted over an intermediate or long-term follow-up.
In comparison with the existing CRT-based method of projection calculation, the suggested method yields a 20%30%% reduction in power consumption, yet requiring by 10%20%% less FPGA resources for implementation.
The individual-level standard logistic regression is the least appropriate method in the analysis of CRTs because it ignores the correlation of the outcomes for the individuals within the same cluster.
Although many papers have compared analytical methods for CRTs with binary outcomes over the last decade, none have investigated the Bayesian model in the analysis of CRT in detail.
However, CRT optimization with traditional echocardiography methods is time consuming and inadequately reimbursed in most countries, resulting in a suboptimal optimization management of CRT recipients.
According to these preliminary findings, systematic CRT optimization represents integral part of the long-term management of CRT patients.
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