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Only 1% of the RCTs reported adequate allocation concealment and 0.6% reported the method of blinding.
172 Explanation—Just as we seek evidence of concealment to assure us that assignment was truly random, we seek evidence of the method of blinding.
This method of blinding eliminates the need for matching placebo manufacturing, and is particularly useful for active-controlled trials requiring comparator blinding.
Efficacy of adjunctive CLB in refractory focal epilepsy was assessed only in a small double-blind, randomized, placebo-controlled, cross-over study hampered by several methodological limitations (unclear allocation concealment, generation of random sequence and method of blinding) [ 14].
In all five trials, the method of blinding of the outcome assessors was not described [36, 37, 38, 39, 40].
Examples are the design of the randomized assignment (conventional, crossover, parallel group, 2 × 2 factorial) or the method of blinding (single or double blinded, open label).
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Blinding will be maintained by trained clinic staff aware of the purpose and methods of blinding.
The commercially sponsored studies conducted after 1993 are likely to have conformed to International Conference on Harmonisation Good Clinical Practice standard and to have been at low risk of bias with regards their sequence generation, allocation concealment and methods of blinding.
There are two main conceptual methods of blinding a CCD camera using infrared (IR) light.
In this study, a new method of blind audio source separation (BASS) of monaural musical harmonic notes is presented.
Recently, researchers implemented sparse component analysis (SCA) to improve the method of blind image separation [19, 20].
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