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The overall method is rigorously tested and evaluated through a number of simulation experiments that involve low and high dimensional data sets.
The final numerical model based on the finite-volume method is rigorously developed and solved using the definition of Riemann problem (Eq. 4) for the entire physical domain and time length of simulation.
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Fourth, methodological error likely played a minor role, because the measurement method was rigorously tested and calibrated, and both telomere length measurements were in line with previously reported mean telomere length in this age range (Slagboom et al. 1994).
In this paper, three particle simulation methods were rigorously evaluated using several quantitative metrics to verify their feasibility for aggregate packing and mixing simulations in which determining the volumetric properties under multiple phases and conditions is essential.
The methods are rigorously compared to each other using several objective measures discussed in literature complementing the initial results reported in [9].
Importantly, in the weak purifying selection limit, the method we used is rigorously insensitive to underlying demographics and merely a function of the underlying Γ distribution of deleterious fitness effects.
The proposed method is validated rigorously with existing literature results.
This method is more rigorously derived than the original modified rate approach.
This method has been rigorously tested through a range of approach conditions to ensure that it is robust enough for use in the design process.
The method has been rigorously evaluated, first with a 5-fold cross-validation within an initial set of 120 images, second with an external set of 30 different images and third with images with artefacts included.
The viability and accuracy of the proposed method has been rigorously tested and verified through comparisons with analytical solutions as well as with the results obtained with a corresponding, previously published, and independently benchmarked solution for 2D Cartesian coordinates.
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