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(Although the method is purely arithmetic, one can interpret it graphically: the tabulated values form a linear "zigzag" approximation to what is actually a sinusoidal variation).
The method is purely automatic and does not require any parameters beyond the determination of k.
Also, since the method is purely based on partial charges, it should perform poorly if the recognition of a binding site by a query ligand is not mostly driven by electrostatics.
The third column annotates each method with specifications; topological versus both indicates if the method is purely based on topological information or both topological and biological information.
This method is purely experimental and you are warned that it can result in some unusable colors.
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What he really means by accepted social science methods is purely materialist analysis.
However, these methods are purely theoretical.
Our methods are purely analytic and completely different from earlier approaches which were implemented under more restrictive assumptions.
However, the results need to be interpreted cautiously, with a full understanding that FEA methods are purely numerical data that are mathematically enumerated.
Some methods are purely geometrical (LIGSITE [13], LIGSITEcs [14], PocketPicker [5]), while others make use of additional physico-chemical information like polarity or charge (MOE SiteFinder [15], Fpocket [9]).
However, most of these clustering methods are purely data-driven with no prior biological knowledge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com