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But a proxy is all they are.Dr Blei and Mr Gerrish are not claiming their method is necessarily a better proxy.
While all work within the comparative method is necessarily hypothetical, in a large language family like Sino-Tibetan or its component parts Sinitic and Tibeto-Burman we can discover a great deal about earlier stages of human society through its use.
I can't say that either method is necessarily the correct method.
If prediction cannot be accomplished, it does not mean that the in vitro method is necessarily invalid.
Although we have explicitly excluded unsuitable habitats (desert, bare or sparsely vegetated ground) and thus, reduced this source of error considerably, our method is necessarily relatively coarse and might still confound finer-scale patterns.
Also, because their focus was on normalizing microarray data, their method is necessarily less direct than ours (they used spiked RNA as a proxy for the gDNA initially present in the sample as opposed to the gDNA itself) and would require precise quantification of genome sizes before being applied to cross-species or cross-ploidy level comparisons.
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"The film shows that no single method was necessarily responsible for solving the manhunt, nor can any single scene taken in isolation fairly capture the totality of efforts the film dramatizes".
Nevertheless, these methods are necessarily constrained: input sequences need to be the same length and only select SVM kernels are supported.
It is acknowledged by some of these same authors elsewhere [ 2] that, given the small numbers of patients with any particular clinical diagnosis in an ICU patient population, these methods are necessarily 'more suited to monitoring changes that affect all patients or the entire clinical process.' The use of real-time process monitoring is of course not new.
Assignments of domain movements to these mechanisms were made by an intuitive method that is necessarily subjective.
Furthermore, the opportunity to perform large evaluation trials to validate new diagnostic methods or treatments is necessarily constrained leading to a relatively limited evidence base with which to inform patient management.
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