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Nevertheless, despite these limitations, we have shown the utility of the SVM method in deciphering the complex interplay of numerous genes involved in a biological pathway through gene expression data of patient samples.
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Together, we developed a high-throughput, SILAC-compatible, and MRM-based kinome profiling method and demonstrated that the method is powerful in deciphering the molecular modes of action of a widespread environmental toxicant.
This method will also be useful in deciphering the structural organization of genomes in other groups of bacteria.
The ability to characterize this complexity remains a challenge with the current analytical methods, and as a consequence, progress in deciphering GAG structure-function relationships has been hindered.
Simple correlation between the expression profile of a transcription factor and its targets is not obvious, and simple clustering based methods have not been very successful in deciphering them [ 86].
While it is not practical to verify each protein individually, alternative methods of isolating phagosomes should prove helpful in deciphering both false positives and false negatives.
To identify these signatures, the intrinsic nonnegativity of mutations mandates employment of a method incorporating a nonnegative constraint and our simulations demonstrate that NMF is effective in deciphering mutational signatures from mutational catalogs.
The analytic hierarchy approach (AHP) developed by Saaty (1980 , 1986 1992) was used in this study as a decision-aiding method to finalize the weights assigned to different themes and their respective features used in deciphering groundwater potentiality.
With the development of better screening methods and updated collections, the potential for discovery of additional nonorthologous complementation pairs will aid in deciphering biological mechanisms that would otherwise be overlooked.
We hope that this work provides further motivation to conduct theoretical research and large-scale data analysis in deciphering the genetic and physiological meaning of gene-environment interactions and to develop more statistical methods for testing gene-environment interactions.
"We are involved in deciphering signals from above.
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