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Opponents of the method have highlighted concerns about potential water contamination and environmental damage, as well as small-scale earthquakes.
Recent applications of the 'think-aloud' method have highlighted its sensitivity to problems specific to the measures under study, such as misinterpretations and inconsistencies between respondents' interpretations and their recorded responses, which may compromise reliability and validity (Darker & French, 2009; French et al., 2007; Kaklamanou, Armitage, & Jones, 2013).
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Recent studies using advanced 3D imaging methods have highlighted the complexity of actin regulation in invadopodia formation and elongation, further elucidated the specific role of some fundamental players (including microtubules in later stages of invadopodia elongation) and provided novel morphological insights [ 25- 27].
At the same time using such complex systems as test-beds for new control methods has highlighted their limitations (e.g. in relation to system identification) and has thus acted as a catalyst for methodological advance.
Hand hygiene authorities including the WHO and U.S. CDC have recognized inherent weaknesses with the current methods and have highlighted the need for improved in vivo efficacy methods, which reflect the use conditions and experience of healthcare practitioners.
13 Despite the different methods employed, these studies have highlighted some useful findings.
Some researchers have attempted to outline methods for the synthesis of qualitative [ 47] and mixed-methods research [ 36, 45] and to build a typology of such reviews [ 41], while others have highlighted methods for knowledge synthesis reviews to inform specific end-user targets such as for management and policy-making in the health field [ 45].
Recent meta-analyses [16],[17] have highlighted several methods for volume delineation - either using percentage or absolute SUV thresholds.
As part of this assessment, we have highlighted appropriate methods that could be employed to close this gap.
The original application of phylogenetic comparative methods such as independent contrasts was for interspecific comparisons, although intraspecific studies have highlighted the utility of these methods within species [ 88- 90].
Several meta-analyses have highlighted the heterogeneity in delivery, methods, and duration of these interventions.
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