This method has substantial limitations since the manufacturing capacity is restricted by the availability of eggs, which may be insufficient to meet the urgent requirements for vaccine during a pandemic [1], [2].
From a computational standpoint, the L1 method has substantial advantages over the random permutation method (beginning with the uncertainty of how many genes to sample at a time in the random permutation/bootstrap method) and is likely to become even more valuable when larger data sets involving more individuals and more irrelevant features (larger CpG arrays) become available.
While particle-resolved methods have substantial benefits for highly detailed simulations, these techniques suffer from high computational cost, motivating efforts to improve their algorithmic efficiency.
Altogether, these methods have substantial limitations in terms of large-scale field application and may raise ethical concerns, especially for human landing catches.
When restricted to multi-building parcels and large multi-unit building parcels, all three geocoding methods had substantial positional error (parcels = 24 m; StreetMap USA = 28 m; TIGER = 37 m).
In addition, computer simulations investigating the performance of methods in detecting selective loci under divergent selection with markers such as AFLPs shows that, despite the methods having substantial uncertainty, the average distance between detected outlier markers and true selective loci ranges between 7 and 18 cM [ 68], in agreement with empirical observations.
Apart from providing valuable data points for scientific experiments, the method also has substantial educational value as a teaching exercise for architectural students to develop an intuitive understanding of contemporary daylight performance metrics, as well as a feeling of how their personal lighting preferences compare to these metrics.
Each of these methods, however, has substantial limitations in this regard.
This increasingly common transport method has provided substantial competition with pipelines in some markets.
In terms of the containing ratio, i.e. the percentage of the observed data bracketed by the respective runoff prediction limits, the modified GLUE method has shown substantial improvements over the original method, in both the calibration and the verification periods.
Background: The PhotoVoice method has shown substantial promise for work with youth in metropolitan areas, yet its potential for use with Latino youth from agricultural areas has not been well documented.
