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Each genetic method has known strengths and liabilities.
The thermodilution method has known limitations that can lead to inaccuracies.
Calculation of regurgitant volume in native valvular disease using the proximal isovelocity surface area (PISA) method has known technical limitations, primarily the geometric assumptions of PISA shape required to calculate effective regurgitant orifice area.
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Although point-based methods have known difficulties when dealing with crossing flies - they still correctly solve between 90% and 95% of our test case set (see Section 3.5) and typically give low certainty values when they are wrong.
Both methods have known limitations.
However, these methods have known limitations such as resulting in measures only tapping a small part of the underlying construct [ 14- 16].
Since then methods have known continuous evolution up to the recent remarkable achievements in blind assessment experiment by the programs QmeanClust [ 12, 13], 3D-Jury [ 14], Pcons [ 15], ModFoldClust [ 16] and others [ 9].
Fractional programming is a nonlinear programming method that has known increasing exposure recently and its importance, in solving concrete problems, is steadily increasing.
Several of the mouse genes identified by our method either have known association with diabetes or suggest new roles for potential targets of study.
The transferability of this method in populations that have known differences in LD structure, like African, Japanese, Chinese, still needs to be determined.
The issue is emerging as one of the toughest tests of Ms. Pelosi's tenure, as she finds herself fending off accusations of hypocrisy from Republicans for criticizing the interrogation methods, even though she had known about them, and from liberal critics who say that she should have raised the alarm earlier if she knew what was transpiring.
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