Unfortunately, these methods generally fail to reproduce experimental thermodynamic response (i.e., excess heat capacity profiles).
The linear algebraic systems (Jacobians) are sparse, nonsymmetric and indefinite, for which standard linear system solvers based on Krylov subspace methods generally fail to converge without appropriate preconditioners.
The rest of the residues are modeled with large errors because the homology modeling methods generally fail to model structural distortions and rigid body shifts, and are unable to recover from misalignments [25] [27].
As much work in philosophy of science over the last half century has indicated, though, nothing much of anything can be learned by this method: the world quite generally fails to supply falsifying evidence.
Despite progress in secondary structure modeling, high-throughput methods have generally failed to determine ncRNA tertiary structures, even at the 1-nm resolution that enables visualization of how helices and functional motifs are positioned in three dimensions.
It can be clearly seen that when considering crowded subtomograms without excluding surrounding structures, our previous method (Xu et al., 2012) generally fails in finding the correct alignment.
In other words, the method is robust in simple situations and with the use of a single array; however, it generally fails when distributed arrays are used, and when early reflections and head orientation issues are to be addressed.
Coating film generally fails by spalling on cooling after prolonged thermal cycling.
However, current business model innovation and design generally fails to sufficiently embrace the sustainability dimension.
Throughout the world, medical care for people with headache generally fails to alleviate these burdens.
