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This is done using imputation (van Megchelen 2010), a method for statistically determining bits of unknown sequence in-between known variations.
We also provide a method for statistically testing the cVC.
As stated in a recent comprehensive review [20], to develop a powerful method for statistically predicting protein subcellular localization, one of the most important things is to formulate the sample of a protein with the core features that have intrinsic correlation with its localization in a cell.
Techniques established for late-stage confirmatory clinical trials provide a straightforward method for statistically testing evidence of biological activity in small patient studies.
For the evaluation of body mass index and the risk of minor injuries we used a method for statistically combining the control groups in the analysis, because for the partner control group a matched analysis was required, which was neither necessary nor feasible in the RDD group.
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This might include: guidance on how to identify positive deviants based on evidence gathered from the existing measurement and positive deviance literature, inclusion criteria for defining deviant practice, and suggested methods for statistically testing the 'deviance' hypothesis.
The presented method for distinguishing statistically meaningful trends should be reasonably uncomplicated for researchers with basic statistics skills and may thus be useful for determining which trends are worth analysing further, for instance with respect to causal factors.
The high jump clearly does not have its version of the Duckworth-Lewis method for these statistically tricky moments and the flags of Qatar and Canada will also be jostling for flag-pole space.
Our new algorithm, PhyloScan, an extension of Staden's method, statistically accounts for the phylogenetic dependence of the species contributing data to the alignment and calculates a p-value for the sequence match in the aligned data set.
As the main purpose of this paper was to evaluate our methods for selecting statistically significant ions from high resolution MALDI-TOF MS data, we did not include biological assessment on the identified panels due to time and financial constraints.
Methods for identifying statistically significant CISs, i.e. regions that are mutated by insertions in significantly more tumours than expected by chance, have involved generating a random distribution of insertions across the genome and obtaining an estimate of the number of false CISs in windows of fixed size using Monte Carlo simulation [214] or the Poisson distribution [175].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com