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Individual sample sizes ranged from 10too 905 participants (median 81 participants); 2.3% of the RCTs were multiple center trials; 63.9% evaluated Western medicine, 32.5% evaluated traditional Chinese medicine; 15% used an adequate method of random sequence generation; and 10.4% used a quasi-random method for randomization.
The design of the trial was not clear as authors reported it as a randomized trial but the method for randomization was not described.
A stratified random sampling scheme was employed as the selection method for randomization.
An envelope-derived method for randomization may be inferior to a computer-based method.
Four of the RCTs had used an optimal method for randomization.
As a method for randomization block randomization with variable sizes is used.
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Report full details on methods and experimental design, including technical and biological replicates, methods for randomization and masking, and self-replication efforts.
(0 = no; 1 = yes) Deduct 1 point if methods for randomization or blinding were inappropriate.
None of the trials reported whether, or how, they concealed allocation of treatment within participants or methods for randomization.
Future trials should adhere to low-risk allocation concealment methods for randomization and include women as well as men.
The quality of the trials was evaluated using Jadad quality scores [ 13], and included secure methods for randomization, allocation concealment, patient and observer blinding, and loss to follow-up.
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