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Given that no gold standard method exists for the methodological assessment of risk factor studies, the questions were drawn from research from a published quality assessment method for randomised and nonrandomised studies [ 23], as well as from research on reporting of prognostic models in the oncology field [ 24, 25].
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Statistical analysis will follow standard methods for randomised trials and the primary analysis will be by intention to treat.
Intention to treat: Method of analysis for randomised controlled trials in which all patients are analysed as they were randomised, regardless of behaviour or treatment received.
Contamination adjusted intention to treat: Method of analysis for randomised controlled trials in which all patients are analysed as they were randomised and then the result adjusted for treatment contamination by using an instrumental variable.
Per protocol: Method of analysis for randomised controlled trials in which individuals are included in the analysis only if they followed the assigned protocol and are removed from the analysis entirely if they do not follow protocol.
As treated: Method of analysis for randomised controlled trials in which all patients are analysed on the basis of the treatment ultimately received, regardless of the treatment to which they were randomly assigned.
We propose and evaluate a new set of ensemble methods for the randomised sphere cover (RSC) classifier.
Macefield et al's 20 recent systematic review of on-site monitoring methods for healthcare randomised controlled trials was only able to include seven multinational articles.
This paper describes the methods for a randomised controlled trial to evaluate the effectiveness of two manual therapy techniques in the treatment of people with cervicogenic dizziness for which there is limited established evidence-based treatment.
The sample size was calculated with the method for pair matched randomised controlled trials described by Hayes and Bennett.
For randomised studies, randomisation methods will be extracted as the primary measure of bias control.
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