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Altogether, we present an efficient method for profiling protein protein interaction domains that provides a biophysical picture of specificity and selectivity.
To develop a method for profiling the collective populations targeted for recruitment by multiple clinical studies addressing the same medical condition using one eligibility feature each time.
Based on the results of the column screening a method for profiling of multiple lipid species from the major lipid classes was developed.
Here, we developed an "iTRAQ -like method for profiTRAQ -likeby stable isotope tagging (FFAST), based on the differential labeling of the carboxyl group and designed to resolve analytical variance, through a methodlexed assay in cells and subcellular forctions.
Leveraging the ability of a Probody therapeutic to bind its target at the site of disease after proteolytic cleavage, we developed a novel method for profiling protease activity in living animals.
Chen was hard at work developing a new method for profiling undamaged mitochondria, while Shaul had discovered a unique set of 44 metabolic genes that were upregulated in certain cancers that expressed mesenchymal markers (which he called the "Mesenchymal Metabolic Signature," or "MMS"), indicating that those cells were acquiring cancerous characteristics.
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Most current methods for profiling the expressed alternatively spliced isoforms of a gene use short read RNAseq to assess the linkage of individual exons and thus require different positions of alternative splicing within a transcript to be examined independently.
High-throughput methods for profiling uncapped RNA termini have been established independently by several groups and are known variously as degradome sequencing, parallel analysis of RNA ends (PARE) and genome-wide mapping of uncapped transcripts (GMUCT) [ 13- 15].
Conclusion: We have described a microarray-based method, MAPCeL, for profiling gene expression in specific C. elegans motor neurons and provide evidence that this approach can reveal candidate genes for key roles in the differentiation and function of these cells.
Results: We demonstrate the greater accuracy of metaMix compared with relevant methods, particularly for profiling complex communities consisting of several related species.
Microarrays would be the method of choice for profiling the entire genome, and CGP may be used to complement it.
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