We evaluated the efficacy of an SPDT method for treating leukemia using a Brown Norway myeloid leukemia (BNML) rat model with the LT12 cells engineered to express GFP.
Therefore, it is very urgent to find a low-cost, highly sensitive, and simple method for detecting leukemia.
At present, the commonly used method for detecting leukemia is taking peripheral blood cells and bone marrow, after that many kinds of analysis [6], including cell morphology, cytochemistry [7 9], immunophenotype [10, 11], immunohistochemical [12, 13], and aptamer-based flow cytometry [14, 15], have been carried out.
Functional screens of small molecules, mostly tyrosine kinase inhibitors, were performed and evaluated for ability to reduce survival of Ki-CA cells according to methods established for leukemias.
Although BM is easily accessible by aspiration through the iliac crest and is a routine diagnostic method for patients with leukemias and lymphomas, BM analysis is an invasive procedure not yet introduced in the clinical management of solid tumor patients.
We applied our method to two microarray datasets for leukemia and prostate cancer.
Our findings indicate that SPDT could be an effective method for the treatment of leukemia, and that antitumor immunity may play a key role in this process.
The aim of the study was to develop an indirect, robust and simple in application method for the detection of bovine leukemia virus antigen gp51.
Results in this work contribute to the development of a novel optical method for the early diagnosis of leukemia.
The problem was that the traditional methods for categorizing the leukemia were imprecise, said Dr. Timothy Ley of Washington University in St . Louis who led the study with Richard Wilson, also of Washington University.
