Sentence examples for method for haplotype from inspiring English sources
One of the challenges of large disease-association studies is developing a fast and accurate computing method for haplotype inference from genotype data.
It has been shown that the best method for haplotype reconstruction when the phase is unknown is also probabilistic and based on MCMC [ 52, 53].
This graph, called the Clark consistency (CC) graph, was first suggested in the context of a method for haplotype phasing by Andrew Clark [ 10].
In the previous section, we described a fast and accurate method for haplotype assembly of diploid species that relies on solving low-rank SDP relaxation of the problem.
The VDR haplotypes were statistically reconstructed from population genotype data using the PHASE program with the Markov chain method for haplotype assignments [ 32].
PHASE (version 2.1), which uses a Bayesian statistical method for haplotype construction (Stephens et al, 2001), was downloaded from http://stephenslab.uchicago.edu/software.html.html
Methods for haplotyping and DNA copy-number typing of single cells are paramount for studying genomic heterogeneity and enabling genetic diagnosis.
TV, MZE and JRV are co-inventors on a submitted patent application PCT/EP2011/060211 (Methods for haplotyping single cells - KU Leuven).
One of these challenges is haplotype inference; methods for haplotype inference designed for small data sets from candidate-gene studies do not scale well to the large number of individuals genotyped in whole-genome association studies.
The most frequently used methods for haplotype reconstruction are based either on the maximum likelihood-based expectation-maximization (EM) algorithm [7] or on a Bayesian framework incorporating the coalescent model [8], [9].
Theory and methods for haplotype discovery have well been established for natural populations [13] in which the non-random association among different single nucleotide polymorphims (SNP), specified by the coefficients of linkage disequilibria, lays a foundation for the mixture model of haplotyping a quantitative trait.
