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Some practical drawbacks make this method difficult to be easily utilized in low-resource laboratories.
An inspection of the whole top-map shows that the compounds in the dataset used are structurally very different which makes the read-across method difficult to apply.
Furthermore, the requirement to register the clinical dataset to smoothed versions of the digital Hoffman brain phantom to determine the appropriate smoothing kernel using a voxel-wise comparison, makes the method difficult to extend to whole body data.
Unfortunately, inconsistencies in the experimental and theoretical parameters make this method difficult to use [ 38].
With a growing number of variables model selection becomes computationally demanding and quickly exceeds feasibility, thereby making the method difficult to adapt to high-dimensional data.
Nevertheless, the graphitic stationary phase is prone to changes in retention properties due to redox processes, which makes the method difficult to interface to mass spectrometry via electrospray ionization.
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She said she finds their methods difficult to explain to her two young daughters.
Lack of the orthogonality of stimulus signal components makes classical analysis methods difficult to apply.
This makes existing usability measurement methods difficult to use, especially for non-professionals.
Although this was done with the aim to make as best the detection as possible, it makes a direct comparison of the proposed method results between the two imaging methods difficult to appraise.
Moreover, unemployed participants found ACASI methods difficult to use probably due to the lack of computer exposure from a work environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com